Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain.

ABSTRACT:

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Complex regional pain syndrome (CRPS) is a chronic condition that involves significant hyperalgesia of the affected limb, typically accompanied by localized autonomic abnormalities and frequently by motor dysfunction. Although central brain systems are thought to play a role in the development and maintenance of CRPS, these systems have not been well characterized. In this study, we used structural magnetic resonance imaging to characterize differences in gray matter volume between patients with right upper extremity CRPS and matched controls. Analyses were carried out using a whole brain voxel-based morphometry approach. The CRPS group showed decreased gray matter volume in several pain-affect regions, including the dorsal insula, left orbitofrontal cortex, and several

SUBMITTER: Barad MJ 

PROVIDER: S-EPMC4784981 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature