Ontology highlight
ABSTRACT:
SUBMITTER: Gierach GL
PROVIDER: S-EPMC4784982 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Gierach Gretchen L GL Patel Deesha A DA Pfeiffer Ruth M RM Figueroa Jonine D JD Linville Laura L Papathomas Daphne D Johnson Jason M JM Chicoine Rachael E RE Herschorn Sally D SD Shepherd John A JA Wang Jeff J Malkov Serghei S Vacek Pamela M PM Weaver Donald L DL Fan Bo B Mahmoudzadeh Amir Pasha AP Palakal Maya M Xiang Jackie J Oh Hannah H Horne Hisani N HN Sprague Brian L BL Hewitt Stephen M SM Brinton Louise A LA Sherman Mark E ME
Cancer prevention research (Philadelphia, Pa.) 20151208 2
Elevated mammographic density (MD) is an established breast cancer risk factor. Reduced involution of terminal duct lobular units (TDLU), the histologic source of most breast cancers, has been associated with higher MD and breast cancer risk. We investigated relationships of TDLU involution with area and volumetric MD, measured throughout the breast and surrounding biopsy targets (perilesional). Three measures inversely related to TDLU involution (TDLU count/mm(2), median TDLU span, median acini ...[more]