Ontology highlight
ABSTRACT:
SUBMITTER: Vann KR
PROVIDER: S-EPMC4785065 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Vann Kendra R KR Ergün Yavuz Y Zencir Sevil S Oncuoglu Serkan S Osheroff Neil N Topcu Zeki Z
Bioorganic & medicinal chemistry letters 20160215 7
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an antineoplastic agent that intercalates into DNA and alters topoisomerase II activity. Unfortunately, this compound displays a number of adverse properties. Therefore, to investigate new ellipticine-based compounds for their potential as topoisomerase II-targeted drugs, we synthesized two novel derivatives, N-methyl-5-demethyl ellipticine (ET-1) and 2-methyl-N-methyl-5-demethyl ellipticinium iodide (ET-2). As determined by DNA decatenati ...[more]