Ontology highlight
ABSTRACT:
SUBMITTER: Lisi GP
PROVIDER: S-EPMC4785347 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lisi George P GP Loria J Patrick JP
Progress in nuclear magnetic resonance spectroscopy 20151207
Conformational motions play an essential role in enzyme function, often facilitating the formation of enzyme-substrate complexes and/or product release. Although considerable debate remains regarding the role of molecular motions in the conversion of enzymatic substrates to products, numerous examples have found motions to be crucial for optimization of enzyme scaffolds, effective substrate binding, and product dissociation. Conformational fluctuations are often rate-limiting to enzyme catalysis ...[more]