Ontology highlight
ABSTRACT:
SUBMITTER: Bi QR
PROVIDER: S-EPMC4785358 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bi Qi-Rui QR Hou Jin-Jun JJ Qi Peng P Ma Chun-Hua CH Feng Rui-Hong RH Yan Bing-Peng BP Wang Jian-Wei JW Shi Xiao-Jian XJ Zheng Yuan-Yuan YY Wu Wan-Ying WY Guo De-An DA
Scientific reports 20160310
Venenum Bufonis (VB) is a widely used traditional medicine with serious cardiotoxic effects. The inflammatory response has been studied to clarify the mechanism of the cardiotoxicity induced by VB for the first time. In the present study, Sprague Dawley (SD) rats, were administered VB (100, 200, and 400 mg/kg) intragastrically, experienced disturbed ECGs (lowered heart rate and elevated ST-segment), increased levels of serum indicators (creatine kinase (CK), creatine kinase isoenzyme-MB (CK-MB), ...[more]