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CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.

ABSTRACT: An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments.

SUBMITTER: Miriagou V

PROVIDER: S-EPMC478546 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.

Miriagou V V Tzouvelekis L S LS Villa L L Lebessi E E Vatopoulos A C AC Carattoli A A Tzelepi E E

Antimicrobial agents and chemotherapy 20040801 8

An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments. ...[more]

PMID: 15273143

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