Ontology highlight
ABSTRACT:
SUBMITTER: Wong GW
PROVIDER: S-EPMC478567 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Wong Guang W GW Wang Jin J Hug Christopher C Tsao Tsu-Shuen TS Lodish Harvey F HF
Proceedings of the National Academy of Sciences of the United States of America 20040701 28
Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. In the present study, we focus on mCTRP2, the mouse paralog ...[more]