Ontology highlight
ABSTRACT:
SUBMITTER: Simon DJ
PROVIDER: S-EPMC4785881 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Simon David J DJ Pitts Jason J Hertz Nicholas T NT Yang Jing J Yamagishi Yuya Y Olsen Olav O Tešić Mark Milica M Molina Henrik H Tessier-Lavigne Marc M
Cell 20160218 5
During development, sensory axons compete for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling driving axon degeneration upon local deprivation is proposed to reside within axons. Our results instead support a model in which, despite the apoptotic machinery being present in axons, the cell body is an active participant in gating axonal caspase activation and axon degeneration. Loss of trophic support in axons initiate ...[more]