Functional Imaging of the Developing Brain at the Bedside Using Diffuse Optical Tomography.

ABSTRACT: While histological studies and conventional magnetic resonance imaging (MRI) investigations have elucidated the trajectory of structural changes in the developing brain, less is known regarding early functional cerebral development. Recent investigations have demonstrated that resting-state functional connectivity MRI (fcMRI) can identify networks of functional cerebral connections in infants. However, technical and logistical challenges frequently limit the ability to perform MRI scans early or repeatedly in neonates, particularly in those at greatest risk for adverse neurodevelopmental outcomes. High-density diffuse optical tomography (HD-DOT), a portable imaging modality, potentially enables early continuous and quantitative monitoring of brain function in infants. We introduce an HD-DO

SUBMITTER: Ferradal SL 

PROVIDER: S-EPMC4785947 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature