Ontology highlight
ABSTRACT:
SUBMITTER: Kuleesha Y
PROVIDER: S-EPMC4785973 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kuleesha Yadav Y Puah Wee Choo WC Wasser Martin M
Royal Society open science 20160210 2
Genes controlling muscle size and survival play important roles in muscle wasting diseases. In Drosophila melanogaster metamorphosis, larval abdominal muscles undergo two developmental fates. While a doomed population is eliminated by cell death, another persistent group is remodelled and survives into adulthood. To identify and characterize genes involved in the development of remodelled muscles, we devised a workflow consisting of in vivo imaging, targeted gene perturbation and quantitative im ...[more]