Ontology highlight
ABSTRACT:
SUBMITTER: Grone BP
PROVIDER: S-EPMC4786103 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Grone Brian P BP Marchese Maria M Hamling Kyla R KR Kumar Maneesh G MG Krasniak Christopher S CS Sicca Federico F Santorelli Filippo M FM Patel Manisha M Baraban Scott C SC
PloS one 20160310 3
Mutations in the synaptic machinery gene syntaxin-binding protein 1, STXBP1 (also known as MUNC18-1), are linked to childhood epilepsies and other neurodevelopmental disorders. Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved sequence and are prominently expressed in the larval zebrafish brain. To understand the functions of stxbp1a and stxbp1b, we generated loss-of-function mutations using CRISPR/Cas9 gene editing and studied brain electrical activity, behavior, development ...[more]