Ontology highlight
ABSTRACT:
SUBMITTER: Thiagarajah JR
PROVIDER: S-EPMC4786374 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Thiagarajah Jay R JR Donowitz Mark M Verkman Alan S AS
Nature reviews. Gastroenterology & hepatology 20150630 8
Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic disorders. Fluid secretion across the intestinal epithelium in secretory diarrhoeas involves multiple ion and solute transporters, as well as activation of cyclic nucleotide and Ca(2+) signalling pathways. In many secretory diarrhoeas, activation of Cl(-) channels in the apical membrane of enterocytes, including the cysti ...[more]