?/? coiled coils.
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ABSTRACT:
SUBMITTER: Hartmann MD
PROVIDER: S-EPMC4786415 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
α/β coiled coils.
Hartmann Marcus D MD Mendler Claudia T CT Bassler Jens J Karamichali Ioanna I Ridderbusch Oswin O Lupas Andrei N AN Hernandez Alvarez Birte B
eLife 20160115
Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail. They do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying heptad repeat of a parallel, trimeric coiled coil. These insertions strain the supercoil to the breakin ...[more]
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