Ontology highlight
ABSTRACT:
SUBMITTER: Kravets E
PROVIDER: S-EPMC4786432 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kravets Elisabeth E Degrandi Daniel D Ma Qijun Q Peulen Thomas-Otavio TO Klümpers Verena V Felekyan Suren S Kühnemuth Ralf R Weidtkamp-Peters Stefanie S Seidel Claus Am CA Pfeffer Klaus K
eLife 20160127
GBPs are essential for immunity against intracellular pathogens, especially for Toxoplasma gondii control. Here, the molecular interactions of murine GBPs (mGBP1/2/3/5/6), homo- and hetero-multimerization properties of mGBP2 and its function in parasite killing were investigated by mutational, Multiparameter Fluorescence Image Spectroscopy, and live cell microscopy methodologies. Control of T. gondii replication by mGBP2 requires GTP hydrolysis and isoprenylation thus, enabling reversible oligom ...[more]