Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
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ABSTRACT:
SUBMITTER: Dunshee DR
PROVIDER: S-EPMC4786731 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Dunshee Diana Ronai DR Bainbridge Travis W TW Kljavin Noelyn M NM Zavala-Solorio Jose J Schroeder Amy C AC Chan Ruby R Corpuz Racquel R Wong Manda M Zhou Wei W Deshmukh Gauri G Ly Justin J Sutherlin Daniel P DP Ernst James A JA Sonoda Junichiro J
The Journal of biological chemistry 20160121 11
FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21. A selective chemical inhibitor, immunodepletion, or genetic deletion of Fap stabilized recombinan ...[more]
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