Ontology highlight
ABSTRACT:
SUBMITTER: Jayaraman P
PROVIDER: S-EPMC4788425 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jayaraman Pushpa P Jacques Miye K MK Zhu Chen C Steblenko Katherine M KM Stowell Britni L BL Madi Asaf A Anderson Ana C AC Kuchroo Vijay K VK Behar Samuel M SM
PLoS pathogens 20160311 3
While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we provide functional evidence for the development T cell exhaustion during chronic TB. Second, we evaluate the role of the inhibitory receptor T cell immunoglobulin and mucin domain-containing-3 (TIM3) d ...[more]