Ontology highlight
ABSTRACT:
SUBMITTER: Heckman-Stoddard BM
PROVIDER: S-EPMC4789107 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Seminars in oncology 20150908 1
Multiple epidemiologic studies have documented an association between the anti-diabetic agent metformin and reduced cancer incidence and mortality. However, this effect has not been consistently demonstrated in animal models or more recent epidemiological studies. The purpose of this paper is to examine metformin's chemopreventive potential by reviewing relevant mechanisms of action, preclinical evidence of efficacy, updated epidemiologic evidence after correction for potential biases and confou ...[more]