Ontology highlight
ABSTRACT:
SUBMITTER: Beck DE
PROVIDER: S-EPMC4789169 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Beck Daniel E DE Lv Wei W Abdelmalak Monica M Plescia Caroline B CB Agama Keli K Marchand Christophe C Pommier Yves Y Cushman Mark M
Bioorganic & medicinal chemistry 20160209 7
Fluorine and chlorine are metabolically stable, but generally less active replacements for a nitro group at the 3-position of indenoisoquinoline topoisomerase IB (Top1) poisons. A number of strategies were employed in the present investigation to enhance the Top1 inhibitory potencies and cancer cell growth inhibitory activities of halogenated indenoisoquinolines. In several cases, the new compounds' activities were found to rival or surpass those of similarly substituted 3-nitroindenoisoquinolin ...[more]