Unknown

Dataset Information

0

Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells.


ABSTRACT: The infection of epithelial cells is a necessary step for Mycobacterium bovis BCG dissemination, but the mechanism of mycobacterial epithelial interactions is not completely understood. Similarly, Streptococcus pyogenes is a strictly human pathogen that favorably colonizes the skin and the pharynx. Effective cytokine secretion is essential in order to fabricate a suitable inflammatory response against an infection. In this data article, the cytokine profile in BCG and S. pyogenes activated THP-1 cell line in media after the acute phase of infection by ELISA is described. The interleukin-8 level was increased in response to both BCG and S. pyogenes, but was quite prominent after 24 h and further increased upto 72 h post infection. On the other hand, an increase in IL-6 response to S. pyogenes was observed while there was no response to BCG even after 48 h of infection. A low level of TNF-? was detected upon BCG and S. pyogenes infection.

SUBMITTER: Verma V 

PROVIDER: S-EPMC4789312 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells.

Verma Vivek V   Kumar Parveen P   Dhanda Rakesh Singh RS   Yadav Manisha M  

Data in brief 20160303


The infection of epithelial cells is a necessary step for Mycobacterium bovis BCG dissemination, but the mechanism of mycobacterial epithelial interactions is not completely understood. Similarly, Streptococcus pyogenes is a strictly human pathogen that favorably colonizes the skin and the pharynx. Effective cytokine secretion is essential in order to fabricate a suitable inflammatory response against an infection. In this data article, the cytokine profile in BCG and S. pyogenes activated THP-1  ...[more]

Similar Datasets

| S-EPMC135468 | biostudies-literature
| S-EPMC8007627 | biostudies-literature
| S-EPMC3094199 | biostudies-literature
| S-EPMC6204702 | biostudies-literature
| S-EPMC4978473 | biostudies-literature
| S-EPMC4344265 | biostudies-literature
| S-EPMC2885305 | biostudies-literature
| S-EPMC4972778 | biostudies-literature
| S-EPMC7558299 | biostudies-literature
| S-EPMC177799 | biostudies-other