Ontology highlight
ABSTRACT:
SUBMITTER: Nagae M
PROVIDER: S-EPMC4789653 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nagae Masamichi M Kanagawa Mayumi M Morita-Matsumoto Kana K Hanashima Shinya S Kizuka Yasuhiko Y Taniguchi Naoyuki N Yamaguchi Yoshiki Y
Scientific reports 20160314
Glycans normally exist as a dynamic equilibrium of several conformations. A fundamental question concerns how such molecules bind lectins despite disadvantageous entropic loss upon binding. Bisected glycan, a glycan possessing bisecting N-acetylglucosamine (GlcNAc), is potentially a good model for investigating conformational dynamics and glycan-lectin interactions, owing to the unique ability of this sugar residue to alter conformer populations and thus modulate the biological activities. Here ...[more]