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Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia.

ABSTRACT: IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women using the TaqMan allelic discrimination real-time PCR method. The CC genotypic distribution of rs153109 was significantly higher among cases than controls (19.1% versus 13.3%, odds ratio [OR]: 1.54, 95% confidence interval [CI]: 1.23-1.93, p?

SUBMITTER: Liu B

PROVIDER: S-EPMC4789744 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia.

Liu Bin B Li Yuan Y Yao Yuan Y Li Hua H Liang Hongda H Xin Miaomiao M Wang Liqin L Zhao Lei L Lin Jizheng J Liu Shiguo S

Scientific reports 20160314

IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women using the TaqMan allelic discrimination real-time PCR method. The CC genotypic distribution of rs153109 ...[more]

PMID: 26971578

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