Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4790086 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Li Songlin S Nie Esther H EH Yin Yuqin Y Benowitz Larry I LI Tung Spencer S Vinters Harry V HV Bahjat F Rena FR Stenzel-Poore Mary P MP Kawaguchi Riki R Coppola Giovanni G Carmichael S Thomas ST
Nature neuroscience 20151026 12
Stroke produces a limited process of neural repair. Axonal sprouting in cortex adjacent to the infarct is part of this recovery process, but the signal that initiates axonal sprouting is not known. Growth and differentiation factor 10 (GDF10) is induced in peri-infarct neurons in mice, non-human primates and humans. GDF10 promotes axonal outgrowth in vitro in mouse, rat and human neurons through TGFβRI and TGFβRII signaling. Using pharmacogenetic gain- and loss-of-function studies, we found that ...[more]