Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.
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ABSTRACT:
SUBMITTER: Sawyer SL
PROVIDER: S-EPMC479043 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Publications
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.
Sawyer Sara L SL Emerman Michael M Malik Harmit S HS
PLoS biology 20040720 9
Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense against retroviral infection involves a single-stranded DNA-editing enzyme, APOBEC3G, that causes hypermutation of HIV. The HIV-encoded virion infectivity factor (Vif) protein targets APOBEC3G for destruction, setting up a genetic conflict between the APOBEC3G and Vif genes. This kind of conflict leads to rapid fixation of mutations that alter a ...[more]
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