Ontology highlight
ABSTRACT:
SUBMITTER: Safi F
PROVIDER: S-EPMC4791135 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Safi Frozan F Shteiman-Kotler Alina A Zhong Yunan Y Iliadi Konstantin G KG Boulianne Gabrielle L GL Rotin Daniela D
Molecular biology of the cell 20160128 6
Drosophila Nedd4 (dNedd4) is a HECT ubiquitin ligase with two main splice isoforms: dNedd4-short (dNedd4S) and -long (dNedd4Lo). DNedd4Lo has a unique N-terminus containing a Pro-rich region. We previously showed that whereas dNedd4S promotes neuromuscular synaptogenesis, dNedd4Lo inhibits it and impairs larval locomotion. To delineate the cause of the impaired locomotion, we searched for binding partners to the N-terminal unique region of dNedd4Lo in larval lysates using mass spectrometry and i ...[more]