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The sweet spot: defining virus-sialic acid interactions.

ABSTRACT: Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.

SUBMITTER: Stencel-Baerenwald JE

PROVIDER: S-EPMC4791167 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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The sweet spot: defining virus-sialic acid interactions.

Stencel-Baerenwald Jennifer E JE Reiss Kerstin K Reiter Dirk M DM Stehle Thilo T Dermody Terence S TS

Nature reviews. Microbiology 20140929 11

Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic ...[more]

PMID: 25263223

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