?3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner.
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ABSTRACT:
SUBMITTER: Fourel L
PROVIDER: S-EPMC4792076 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
β3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner.
Fourel Laure L Valat Anne A Faurobert Eva E Guillot Raphael R Bourrin-Reynard Ingrid I Ren Kefeng K Lafanechère Laurence L Planus Emmanuelle E Picart Catherine C Albiges-Rizo Corinne C
The Journal of cell biology 20160307 6
Understanding how cells integrate multiple signaling pathways to achieve specific cell differentiation is a challenging question in cell biology. We have explored the physiological presentation of BMP-2 by using a biomaterial that harbors tunable mechanical properties to promote localized BMP-2 signaling. We show that matrix-bound BMP-2 is sufficient to induce β3 integrin-dependent C2C12 cell spreading by overriding the soft signal of the biomaterial and impacting actin organization and adhesion ...[more]
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