Ontology highlight
ABSTRACT:
SUBMITTER: Singh W
PROVIDER: S-EPMC4792301 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Singh Warispreet W Fields Gregg B GB Christov Christo Z CZ Karabencheva-Christova Tatyana G TG
RSC advances 20160101 28
Collagenolysis is catalyzed by enzymes from the matrix metalloproteinase (MMP) family, where one of the most studied is MMP-1. The X-ray crystallographic structure of MMP-1 complexed with a collagen-model triple-helical peptide (THP) provided important atomistic information, but few details on the effects of the conformational flexibility on catalysis. In addition, the role of the linker region between the catalytic (CAT) and hemopexin-like (HPX) domains was not defined. In order to reveal the d ...[more]