Ontology highlight
ABSTRACT:
SUBMITTER: Cimas FJ
PROVIDER: S-EPMC4792544 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cimas Francisco J FJ Callejas-Valera Juan L JL Pascual-Serra Raquel R García-Cano Jesus J Garcia-Gil Elena E De la Cruz-Morcillo Miguel A MA Ortega-Muelas Marta M Serrano-Oviedo Leticia L Gutkind J Silvio JS Sánchez-Prieto Ricardo R
Oncotarget 20151201 42
The adenoviral gene E1a is known to enhance the antitumor effect of cisplatin, one of the cornerstones of the current cancer chemotherapy. Here we study the molecular basis of E1a mediated sensitivity to cisplatin in an experimental model of Non-small cell lung cancer. Our data show how E1a blocks the induction of autophagy triggered by cisplatin and promotes the apoptotic response in resistant cells. Interestingly, at the molecular level, we present evidences showing how the phosphatase MKP1 is ...[more]