Ontology highlight
ABSTRACT:
SUBMITTER: Hickey TE
PROVIDER: S-EPMC4792588 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Hickey Theresa E TE Irvine Connie M CM Dvinge Heidi H Tarulli Gerard A GA Hanson Adrienne R AR Ryan Natalie K NK Pickering Marie A MA Birrell Stephen N SN Hu Dong Gui DG Mackenzie Peter I PI Russell Roslin R Caldas Carlos C Raj Ganesh V GV Dehm Scott M SM Plymate Stephen R SR Bradley Robert K RK Tilley Wayne D WD Selth Luke A LA
Oncotarget 20151201 42
The importance of androgen receptor (AR) signaling is increasingly being recognized in breast cancer, which has elicited clinical trials aimed at assessing the efficacy of androgen deprivation therapy (ADT) for metastatic disease. In prostate cancer, resistance to ADT is frequently associated with the emergence of androgen-independent splice variants of the AR (AR variants, AR-Vs) that lack the LBD and are constitutively active. Women with breast cancer may be prone to a similar phenomenon. Here ...[more]