Dataset Information

Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy.

ABSTRACT:

Background

Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis.

Methods

We retrospectively analysed 112 patients treated with CRRT at Skåne University Hospital, Sweden. The control group was treated with Hemosol(®) B0 (no phosphate; n = 36) as dialysis and replacement fluid, while the study group received Phoxilium(®) (phosphate; n = 76) as dialysis fluid and Hemosol(®) B0 as replacement fluid.

Results

Hypophosphataemia (<0.7 mM) occurred in 15% of the treatment days in the control group compared with 7% in the study group (P = 0.027). Magnesium substitution was reduced by 40% in the study group (P < 0.001). No differences in acid-base parameters were detected between the groups.

Conclusions

In this larger cohort, we could confirm that Phoxilium(®) reduced the episodes of hypophosphataemia during CRRT. A beneficial effect on magnesium balance could also be observed.

SUBMITTER: Godaly G

PROVIDER: S-EPMC4792612 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Publications

Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy.

Godaly Gabriela G Carlsson Ola O Broman Marcus M

Clinical kidney journal 20151219 2

<h4>Background</h4>Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis.<h4>Methods</h4>We retrospectively analysed 112 patients treated with CRRT at Skåne University Hospital, Sweden. The control group was treated with Hemosol(®) ...[more]

PMID: 26985370

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Dataset Information

Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy.

Background

Methods

Results

Conclusions

Publications

Phoxilium(®) reduces hypophosphataemia and magnesium supplementation during continuous renal replacement therapy.

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