Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin.
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ABSTRACT:
SUBMITTER: Piotrowski-Daspit AS
PROVIDER: S-EPMC4792648 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin.
Piotrowski-Daspit Alexandra S AS Tien Joe J Nelson Celeste M CM
Integrative biology : quantitative biosciences from nano to macro 20160301 3
Many solid tumors exhibit elevated interstitial fluid pressure (IFP). This elevated pressure within the core of the tumor results in outward flow of interstitial fluid to the tumor periphery. We previously found that the directionality of IFP gradients modulates collective invasion from the surface of patterned three-dimensional (3D) aggregates of MDA-MB-231 human breast cancer cells. Here, we used this 3D engineered tumor model to investigate the molecular mechanisms underlying IFP-induced chan ...[more]
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