Ontology highlight
ABSTRACT:
SUBMITTER: Deritei D
PROVIDER: S-EPMC4793241 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Deritei Dávid D Aird William C WC Ercsey-Ravasz Mária M Regan Erzsébet Ravasz ER
Scientific reports 20160316
Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We posit that distinct phenotype-combinations are generated by interactions among robust regulatory switches, each in control of a discrete set of phenotypic outcomes. First, we demonstra ...[more]