Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC4793269 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Wang Han H Sun Zhongyang Z Wang Yixuan Y Hu Zebing Z Zhou Hua H Zhang Lianchang L Hong Bo B Zhang Shu S Cao Xinsheng X
Scientific reports 20160316
MicroRNAs (miRNAs) interfere with the translation of specific target mRNAs and are thought to thereby regulate many cellular processes. However, the role of miRNAs in osteoblast mechanotransduction remains to be defined. In this study, we investigated the ability of a miRNA to respond to different mechanical environments and regulate mechano-induced osteoblast differentiation. First, we demonstrated that miR-33-5p expressed by osteoblasts is sensitive to multiple mechanical environments, microgr ...[more]