Ontology highlight
ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC4793274 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151125 9
Meiotic recombination hotspots are associated with histone post-translational modifications and open chromatin. However, it remains unclear how histone modifications and chromatin structure regulate meiotic recombination. Here, we identify acetylation of histone H4 at Lys44 (H4K44ac) occurring on the nucleosomal lateral surface. We show that H4K44 is acetylated at pre-meiosis and meiosis and displays genome-wide enrichment at recombination hotspots in meiosis. Acetylation at H4K44 is required fo ...[more]