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Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces.


ABSTRACT: Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid ?. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio?=?3.3, 95% confidence interval 1.3-7.9, p?=?0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.

SUBMITTER: van Veluw SJ 

PROVIDER: S-EPMC4794108 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces.

van Veluw Susanne J SJ   Biessels Geert Jan GJ   Bouvy Willem H WH   Spliet Wim Gm WG   Zwanenburg Jaco Jm JJ   Luijten Peter R PR   Macklin Eric A EA   Rozemuller Annemieke Jm AJ   Gurol M Edip ME   Greenberg Steven M SM   Viswanathan Anand A   Martinez-Ramirez Sergi S  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20151207 3


Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilati  ...[more]

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