Ontology highlight
ABSTRACT:
SUBMITTER: Dubinsky MC
PROVIDER: S-EPMC4794130 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Dubinsky Marla C MC Rosh Joel J Faubion William A WA Kierkus Jaroslaw J Ruemmele Frank F Hyams Jeffrey S JS Eichner Samantha S Li Yao Y Huang Bidan B Mostafa Nael M NM Lazar Andreas A Thakkar Roopal B RB
Inflammatory bowel diseases 20160401 4
<h4>Background</h4>The efficacy of adalimumab in inducing and maintaining remission in children with moderately to severely active Crohn's disease was shown in the IMAgINE 1 trial (NCT00409682). As per protocol, nonresponders or patients experiencing flare(s) on every other week (EOW) maintenance dosing could escalate to weekly dosing; we aimed to determine the therapeutic benefits of weekly dose escalation in this subpopulation.<h4>Methods</h4>Week 52 remission and response rates were assessed ...[more]