Ontology highlight
ABSTRACT:
SUBMITTER: Khoshnejad M
PROVIDER: S-EPMC4794355 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Khoshnejad Makan M Shuvaev Vladimir V VV Pulsipher Katherine W KW Dai Chuanyun C Hood Elizabeth D ED Arguiri Evguenia E Christofidou-Solomidou Melpo M Dmochowski Ivan J IJ Greineder Colin F CF Muzykantov Vladimir R VR
Bioconjugate chemistry 20160115 3
Targeting nanocarriers to the endothelium, using affinity ligands to cell adhesion molecules such as ICAM-1 and PECAM-1, holds promise to improve the pharmacotherapy of many disease conditions. This approach capitalizes on the observation that antibody-targeted carriers of 100 nm and above accumulate in the pulmonary vasculature more effectively than free antibodies. Targeting of prospective nanocarriers in the 10-50 nm range, however, has not been studied. To address this intriguing issue, we c ...[more]