Ontology highlight
ABSTRACT:
SUBMITTER: Gallart-Palau X
PROVIDER: S-EPMC4794845 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Gallart-Palau Xavier X Lee Benjamin S T BS Adav Sunil S SS Qian Jingru J Serra Aida A Park Jung Eun JE Lai Mitchell K P MK Chen Christopher P CP Kalaria Raj N RN Sze Siu Kwan SK
Molecular brain 20160317
<h4>Background</h4>Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer's disease with cerebrovascular disease (AD + CVD).<h4>Results</h4>We detected modulation of several redox proteins in the temporal lobe of AD + CVD subjects, and we observed sex-specific alterations in the ...[more]