Ontology highlight
ABSTRACT:
SUBMITTER: Yeo GC
PROVIDER: S-EPMC4795673 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yeo Giselle C GC Tarakanova Anna A Baldock Clair C Wise Steven G SG Buehler Markus J MJ Weiss Anthony S AS
Science advances 20160205 2
The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly. We explore the structure-dynamics-function interplay, consider the duality of molecular order and disorder, and identify equally significant functional contributions by local and global structures. To study these organizational stratifications, we perturb a key hinge region by expressing an exon tha ...[more]