Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.
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ABSTRACT:
SUBMITTER: Datta M
PROVIDER: S-EPMC4795989 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.
Datta Meenal M Via Laura E LE Chen Wei W Baish James W JW Xu Lei L Barry Clifton E CE Jain Rakesh K RK
Annals of biomedical engineering 20150808 4
Pulmonary granulomas--the hallmark of Mycobacterium tuberculosis (MTB) infection--are dense cellular lesions that often feature regions of hypoxia and necrosis, partially due to limited transport of oxygen. Low oxygen in granulomas can impair the host immune response, while MTB are able to adapt and persist in hypoxic environments. Here, we used a physiologically based mathematical model of oxygen diffusion and consumption to calculate oxygen profiles within the granuloma, assuming Michaelis-Men ...[more]
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