Age-dependent variability in gene expression in male Fischer 344 rat retina.

ABSTRACT: Recent evidence suggests that older adults may be a sensitive population with regard to environmental exposure to toxic compounds. One source of this sensitivity could be an enhanced variability in response. Studies on phenotypic differences have suggested that variation in response does increase with age. However, few reports address the question of variation in gene expression as an underlying cause for increased variability of phenotypic response in the aged. In this study, we utilized global analysis to compare variation in constitutive gene expression in the retinae of young (4 months), middle-aged (11 months), and aged (23 months) Fischer 344 rats. Three hundred and forty transcripts were identified in which variance in expression increased from 4 to 23 months of age, while only 12 t

SUBMITTER: Li Z 

PROVIDER: S-EPMC4796736 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature