Ontology highlight
ABSTRACT:
SUBMITTER: Ruan Y
PROVIDER: S-EPMC4796893 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ruan Yunfeng Y Jiang Jie J Guo Liang L Li Yan Y Huang Hailiang H Shen Lu L Luan Mengqi M Li Mo M Du Huihui H Ma Cheng C He Lin L Zhang Xiaoqing X Qin Shengying S
Scientific reports 20160318
Epidermal growth factor receptor (EGFR) Tyrosine kinase inhibitor (TKI) is an effective targeted therapy for advanced non-small cell lung cancer (NSCLC) but also causes adverse drug reactions (ADRs) e.g., skin rash and diarrhea. SNPs in the EGFR signal pathway, drug metabolism/ transport pathways and miRNA might contribute to the interpersonal difference in ADRs but biomarkers for therapeutic responses and ADRs to TKIs in Chinese population are yet to be fully investigated. We recruited 226 Chin ...[more]