Ontology highlight
ABSTRACT:
SUBMITTER: Wolf D
PROVIDER: S-EPMC4797271 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Wolf Diana D Rippa Valentina V Mobarec Juan Carlos JC Sauer Patricia P Adlung Lorenz L Kolb Peter P Bischofs Ilka B IB
Nucleic acids research 20151117 5
ComA-like transcription factors regulate the quorum response in numerous Gram-positive bacteria. ComA proteins belong to the tetrahelical helix-turn-helix superfamily of transcriptional activators, which bind as homodimers to inverted sequence repeats in the DNA. Here, we report that ComA from Bacillus subtilis recognizes a topologically distinct motif, in which the binding elements form a direct repeat. We provide in vitro and in vivo evidence that the canonical and non-canonical site play an i ...[more]