Ontology highlight
ABSTRACT:
SUBMITTER: Bartlett EJ
PROVIDER: S-EPMC4797286 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bartlett Edward J EJ Brissett Nigel C NC Plocinski Przemyslaw P Carlberg Tom T Doherty Aidan J AJ
Nucleic acids research 20150923 5
The non-homologous end-joining (NHEJ) pathway repairs DNA double-strand breaks (DSBs) in all domains of life. Archaea and bacteria utilize a conserved set of multifunctional proteins in a pathway termed Archaeo-Prokaryotic (AP) NHEJ that facilitates DSB repair. Archaeal NHEJ polymerases (Pol) are capable of strand displacement synthesis, whilst filling DNA gaps or partially annealed DNA ends, which can give rise to unligatable intermediates. However, an associated NHEJ phosphoesterase (PE) resec ...[more]