Ontology highlight
ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC4797303 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Meng Xing X Jiang Qian Q Chang Nannan N Wang Xiaoxia X Liu Chujun C Xiong Jingwei J Cao Huiqing H Liang Zicai Z
Nucleic acids research 20160211 5
RNA activation (RNAa) is the upregulation of gene expression by small activating RNAs (saRNAs). In order to investigate the mechanism by which saRNAs act in RNAa, we used the progesterone receptor (PR) gene as a model, established a panel of effective saRNAs and assessed the involvement of the sense and antisense strands of saRNA in RNAa. All active saRNAs had their antisense strand effectively incorporated into Ago2, whereas such consistency did not occur for the sense strand. Using a distal ho ...[more]