Production and Transport of Gaseous ¹⁸F-Synthons: ¹⁸F-Acyl Fluorides.

ABSTRACT: Fluorine-18 (¹⁸F, T _1/2=109.7 min) is a positron-emitting isotope that has found extensive application as a radiolabel for positron emission tomography (PET). Although gaseous ¹¹C-CO₂ and ¹¹C-CH₄ are practically transported from cyclotron to radiochemistry processes, ¹⁸F-fluoride is routinely transported in aqueous solution because it is commonly produced by proton irradiation of ¹⁸O-enriched water. In most cases, subsequent dry-down steps are necessary to prepare reactive ¹⁸F-fluoride for radiofluorination. In this work, a simple module was designed to generate gaseous ¹⁸F-acyl fluorides from aqueous ¹⁸F-fluoride solution by solid phase ¹⁸F-radiofluorination

SUBMITTER: Jiang H 

PROVIDER: S-EPMC4797647 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature