Ontology highlight
ABSTRACT:
SUBMITTER: Arbor SC
PROVIDER: S-EPMC4797837 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Arbor Sage C SC LaFontaine Mike M Cumbay Medhane M
The Yale journal of biology and medicine 20160324 1
Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeuti ...[more]