Ca-Dependent Folding of Human Calumenin.
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ABSTRACT:
SUBMITTER: Mazzorana M
PROVIDER: S-EPMC4798761 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Ca-Dependent Folding of Human Calumenin.
Mazzorana Marco M Hussain Rohanah R Sorensen Thomas T
PloS one 20160318 3
Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly ...[more]
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