Ontology highlight
ABSTRACT:
SUBMITTER: Theodoropoulos PC
PROVIDER: S-EPMC4798879 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature chemical biology 20160201 4
A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic at low nanomolar concentrations to the same 4 of 12 human lung cancer cell lines. Sensitive cell lines expressed cytochrome P450 (CYP) 4F11, which metabolized the compounds into irreversible inhibitors of stearoyl CoA desaturase (SCD). SCD is r ...[more]