Ontology highlight
ABSTRACT:
SUBMITTER: Lombardi LR
PROVIDER: S-EPMC4798915 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lombardi Lindsey R LR Kanakry Christopher G CG Zahurak Marianna M Durakovic Nadira N Bolaños-Meade Javier J Kasamon Yvette L YL Gladstone Douglas E DE Matsui William W Borrello Ivan I Huff Carol Ann CA Swinnen Lode J LJ Brodsky Robert A RA Ambinder Richard F RF Fuchs Ephraim J EJ Rosner Gary L GL Jones Richard J RJ Luznik Leo L
Leukemia & lymphoma 20151012 3
Busulfan (Bu)/cyclophosphamide (Cy) is a standard conditioning platform for allogeneic transplantation. We developed a strategy separating the Cy into two pre/post-transplantation doses (PTCy), providing myeloablative conditioning and single-agent graft-versus-host disease (GVHD) prophylaxis. We investigated the impact of Bu route on treatment-related toxicity for 131 consecutive adult patients. Busulfan was administered in four daily divided doses either orally (n = 72) or intravenously (n = 59 ...[more]